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VOLUME 3 , ISSUE 1 ( January-June, 2019 ) > List of Articles


Correlation of Hyperhomocysteinemia with the Severity of Pregnancy-induced Hypertension—A Case–Control Study

Guljit Kaur, Bhakti Kohli, Reena Sood

Keywords : Folic acid, Homocysteine, Preeclampsia, Pregnancy-induced hypertension, HELLP syndrome

Citation Information : Kaur G, Kohli B, Sood R. Correlation of Hyperhomocysteinemia with the Severity of Pregnancy-induced Hypertension—A Case–Control Study. Curr Trends Diagn Treat 2019; 3 (1):23-26.

DOI: 10.5005/jp-journals-10055-0068

License: CC BY-NC 4.0

Published Online: 01-06-2018

Copyright Statement:  Copyright © 2019; The Author(s).


Background: Hypertension is the most common medical problem encountered during pregnancy and is a major cause of maternal morbidity and mortality. Serum homocysteine-mediated vascular changes are similar to those associated with preeclampsia and, hence, hypothesized to be associated with this condition. The present study is being undertaken to study the association of serum homocysteine with pregnancy-induced hypertension (PIH) and folic acid supplementation. Materials and methods: This is a prospective study conducted in a tertiary care teaching hospital in Punjab. The study was carried out for a period of 2 years. This study included 60 pregnant women, out of which 30 subjects were having hypertensive disorders of pregnancy and 30 were normotensive subjects. Fasting serum homocysteine levels were obtained, compared, and analyzed. The test was based on an immunoassay technique. The normal range of serum homocysteine was taken as 5–15 µmol/L. Results: In this study, serum homocysteine levels were found to be higher in hypertensive subjects as compared to that in normotensive subjects. The levels of serum homocysteine were higher in severe forms of PIH in comparison to nonsevere forms. Also, the level of serum homocysteine was associated with folic acid supplementation. Conclusion: In summary, the present study has shown an increased level of serum homocysteine in both mild and severe preeclampsia compared with normal pregnancy and a statistically significant association of total homocysteine concentrations with the severity of the disease.

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