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VOLUME 3 , ISSUE 2 ( July-December, 2019 ) > List of Articles
Rajat Sharma, Mohit Sharma, Sanchit Bansal, Karaninder Singh, Neeti R Singh
Keywords : Radical treatment, Retroperitoneal liposarcoma, Soft-tissue sarcomas,Myxoid areas
Citation Information : Sharma R, Sharma M, Bansal S, Singh K, Singh NR. A Huge Retroperitoneal Liposarcoma: A Case Report. Curr Trends Diagn Treat 2019; 3 (2):90-92.
License: CC BY-NC 4.0
Published Online: 18-07-2020
Copyright Statement: Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd.
Aim: Retroperitoneal soft-tissue sarcomas are relatively uncommon diseases, and the most frequent histotype, ranging from 20 to 45% of all cases, is represented by liposarcoma, which is a hard-to-treat condition for its local aggressiveness and clinical aspecificity. Presentation of case: We report a case of a 69-year-old woman who underwent surgical resection for a giant pleomorphic retroperitoneal liposarcoma. Discussion: Currently, chemotherapy for retroperitoneal soft-tissue sarcomas is not effective, and radiotherapy has limited efficacy due to the toxicity affecting adjacent intra-abdominal structures and showed validity only in case of high-grade malignancy by reducing local recurrence but with no advantage in overall survival. Nowadays, complete surgical resection remains the most important predictor of local recurrence and overall survival. Conclusion: The removal of a retroperitoneal sarcoma of remarkable size is a challenge for the surgeon owing to the anatomical site, the absence of an anatomically evident vascular-lymphatic peduncle, and the adhesions contracted with the contiguous organs and great vessels. Therefore, we believe that, particularly for large-sized diseases associated with high-grade malignancy, a complete surgical resection with the removal of the contiguous intra- and retroperitoneal organs when infiltrated represents the only therapeutic option to obtain a negative margin and therefore an oncological radicality.
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