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VOLUME 4 , ISSUE 1 ( January-June, 2020 ) > List of Articles


Mixed Adenoneuroendocrine Carcinoma: A Case Report

Manas Madan, Pavneet Bhatia, Manisha Sharma, Mridu Manjari

Citation Information : Madan M, Bhatia P, Sharma M, Manjari M. Mixed Adenoneuroendocrine Carcinoma: A Case Report. Curr Trends Diagn Treat 2020; 4 (1):38-40.

DOI: 10.5005/jp-journals-10055-0088

License: CC BY-NC 4.0

Published Online: 16-06-2020

Copyright Statement:  Copyright © 2020; The Author(s).


Introduction: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare tumor of the gastrointestinal tract which consists of a dual adenocarcinomatous and neuroendocrine differentiation, each component representing at least 30% of the tumor. Case description: A 60-year-old women presented with complaint of upper abdominal pain and difficulty in swallowing solid food. Endoscopy revealed linitis plastica. Contrast-enhanced computed tomography abdomen revealed a diffuse stomach wall thickening in region of fundus and body with enhancing nodular lesions likely mitotic etiology along with upper abdominal lymphadenopathy. Patient underwent total gastrectomy. Grossly there was a grey white growth at the antrum measuring 3.5 × 2 cm in size with multiple satellite nodules. Histopathological report revealed tumor cells, forming glandular pattern. Amidst these there was also present a second population of small monomorphic cells forming insular pattern. Twenty out of 25 lymph nodes showed secondary carcinomatous deposits. Diagnosis of MANEC was proposed which was confirmed on immunohistochemistry with immunopositivity for synaptophysin/chromogranin and immunonegativity for CK7/CK20/CEA. Patient received chemotherapy and 25 cycles of radiotherapy but presented again with hepatic deposits within 6 months. Conclusion: The case is worth reporting because of its rare presentation. Close attention should be paid to such patients, as MANEC can be a highly aggressive tumor, showing rapid progression and metastasis.

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