Dengue is an arthropod-borne viral infection caused by genus flavivirus. The most important flaviviruses that cause fever and myalgia syndrome are dengue viruses 1–4. Dengue viral infection causes many complications such as pneumonia, bone marrow failure, hepatitis, retinal hemorrhages, maculopathy, and myositis. Neurologic complications such as encephalitis, Guillain–Barre syndrome, phrenic neuropathy, subdural hematoma, and cerebral vasculitis are less common. Limited case series have indicated the possibility of skeletal muscle invasion causing myositis. We present a case of a 54-year-old male who presented with high-grade fever and muscular pain in both upper and lower limbs. His serum creatine kinase (CPK) value was 619 U/L. He was managed conservatively and low-dose corticosteroids were given. Our case highlights the severe muscle involvement in dengue infection which is a rare entity.
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