Words and definitions frame our understanding. In learning physiology, precise words used that explain specific physiology help to conceptualize essential homeostatic events in the body. The combination of two keywords into one (portmanteau) can effectively aid the appreciation of physiological mechanisms. For example, the portmanteau “natriuresis” expresses the dual responses in the urinary excretion of excess water and sodium during renal compensation for both positive sodium and positive water status. Physiology teachers can create their own portmanteau to engage their classes. Students can also try integrating words to make physiology portmanteau to stimulate and summarize their own understanding.