Citation Information :
Sharma N, Goyal JL, Gahlot A. Recurrence of Herpes Simplex Keratitis in Corneal Grafts. Curr Trends Diagn Treat 2023; 7 (1):14-16.
Recurrence of herpes simplex virus (HSV) keratitis is a possible complication of keratoplasty done for corneal scars resulting from herpes simplex keratitis. Prognosis is often poor. A couple of months ago, a 38-year-old woman with penetrating keratoplasty operated for herpes simplex keratitis two years back presented to us with corneal oedema in the left eye with vision of counting fingers at one foot. We prescribed her topical steroids, and she improved significantly but she failed to come for follow-up regularly. Last week, she presented to us again and had unfortunately developed epithelial dendritic keratitis (stain positive) along with minimal corneal oedema. This time, we treated her with topical acivir and discontinued previously prescribed steroids. She responded dramatically well to acivir with disappearance of dendrites, within 4 days, but her corneal oedema increased again. Hence, we have started her on oral steroids along with topical acivir, mild topical steroids, and hypersol. She improved her vision from 3/60 to 6/24. She is now on regular follow-up.
Borkar DS, Gonzales JA, Tham VM, et al. Association between atopy and herpetic eye disease: Results from the pacific ocular inflammation study. JAMA Ophthalmol 2014;132(3):326–331. DOI: 10.1001/jamaophthalmol.2013.6277.
Roozbahani M, Hammersmith KM. Management of herpes simplex virus epithelial keratitis. Curr Opin Ophthalmol 2018;29(4):360–364. DOI: 10.1097/ICU.0000000000000483.
Nijm LM, Feldman BH, Kozak A, et al. Herpes Simplex Epithelial Keratitis. American Academy of Ophthalmology. Available from: https://eyewiki.aao.org/Herpes_Simplex_Epithelial_Keratitis. Last Accessed date: 06 March 2023.
White ML, Chodosh J. Herpes simplex virus keratitis: A treatment guideline. AAO compendium of evidence-based eye care; 2014. Available from: http://www.aao.org/clinical-statement/herpes-simplex-virus-keratitis-treatment-guideline. Last Accessed on: 26 October 2015.
Ching SST, Feder RS, Hindman HB, et al. Herpes simplex epithelial keratitis. Preferred practice pattern clinical questions. Am Acad Ophthalmol 2012;1–8.
Wilhelmus KR. Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev 2015;1:CD002898.
Kalogeropoulos D, Geka A, Malamos K, et al. New therapeutic perceptions in a patient with complicated herpes simplex virus 1 keratitis: A case report and review of the literature. Am J Case Rep 2017;18:1382–1389. DOI: 10.12659/ajcr.906506.
Austin A, Lietman T, Rose-Nussbaumer J. Update on the management of infectious keratitis. Ophthalmology 2017;124(11):1678–1689. DOI: 10.1016/j.ophtha.2017.05.012.
Liesegang TJ, Melton LJ, Daly PJ, et al. Epidemiology of ocular herpes simplex. Natural history in Rochester, Minn, 1950 through 1982. Arch Ophthalmol 1989;107(8):1160–1165. DOI: 10.1001/archopht.1989.01070020226030.
