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VOLUME 7 , ISSUE 2 ( July-December, 2023 ) > List of Articles


Progressive Multifocal Leukoencephalopathy in an HIV-positive Patient: A Case Report

Avi Singh Gandh

Keywords : AIDS-related progressive multifocal leukoencephalopathy, Antiretroviral therapy, Case report, Human immunodeficiency virus, Immunosuppression, John Cunningham virus

Citation Information : Gandh AS. Progressive Multifocal Leukoencephalopathy in an HIV-positive Patient: A Case Report. Curr Trends Diagn Treat 2023; 7 (2):53-54.

DOI: 10.5005/jp-journals-10055-0168

License: CC BY-NC 4.0

Published Online: 26-03-2024

Copyright Statement:  Copyright © 2023; The Author(s).


Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease that occurs as a complication (4–8%) of the John Cunningham (JC) virus in oligodendritic cells. Progressive multifocal leukoencephalopathy is characterized by focal neurological deficits that usually show insidious onset and steady progression. Since the demyelinating lesions can affect various areas of the brain, specific deficits differ from patient to patient. Patients with PML tend to have a prolonged course with multifocal neurological deficits, such as ataxia, hemiparesis, aphasia, and visual field defects that may occur with or without a change in mental status. Here, we present the case of an human immunodeficiency virus (HIV)-positive patient who initially presented with severe headache, vomiting, and generalized weakness, leading to the diagnosis of PML.

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