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VOLUME 3 , ISSUE 2 ( July-December, 2019 ) > List of Articles

ORIGINAL RESEARCH ARTICLE

Incidence and Clinicopathological Correlation of Cervical Cancer in a Tertiary Care Center: A 5-year Retrospective Study

Arshdeep Kaur, Amisha Chawla, Mridu Manjari

Keywords : Cervical cancer, Clinicopathological profile, Risk factors

Citation Information : Kaur A, Chawla A, Manjari M. Incidence and Clinicopathological Correlation of Cervical Cancer in a Tertiary Care Center: A 5-year Retrospective Study. Curr Trends Diagn Treat 2019; 3 (2):64-67.

DOI: 10.5005/jp-journals-10055-0078

License: CC BY-NC 4.0

Published Online: 01-12-2019

Copyright Statement:  Copyright © 2019; The Author(s).


Abstract

Introduction: Cervical carcinoma is the second most common cancer of women in India, with the first being breast carcinoma. In 2018, the age standardized incidence rate in the world was 13.1% and in India was14.7%, with 569,847 new cases and 311,365 deaths in 2018 in the world. Infection by human papillomavirus (HPV) is the most common risk factor for cervical cancer, with more than 99% cases expressing viral sequence. The present study was undertaken to study the incidence, various clinical presentations, and the histological types of cervical carcinoma. Materials and methods: The study was carried out in a tertiary care center for a period of 5 years (January 2015 to December 2019) on histopathologically diagnosed cases of cervical cancer. A total of 308 cases of cervical carcinoma were studied in this period. Results: Incidence of cervical cancer in the present study was 2.9%. Maximum number of cases was seen in fifth and sixth decades. The most common clinical presentation was postmenopausal bleeding (78.6%) followed by discharge per vaginam (66.6%). On microscopy, squamous cell carcinoma (SCC)-large-cell nonkeratinizing type was most common (89%) followed by adenocarcinoma (5.5%). Other types were adenosquamous (1.9%) and small cell carcinoma (1.9%), and the least common was SCC-large-cell keratinizing type (1.6%). Of the 308 cases, 164 (53.2%) were in stage II followed by 95 cases (30.2%) in stage I. Conclusion: In conclusion, the current study stressed the fact that as a majority of Indian women are diagnosed at later stages of cervical cancer rather than in its early treatable stages, so there is a need for strengthening and proper implementation of screening programs. Keeping in mind the incidence, the knowledge of vaccination against HPV for prevention of carcinoma cervix should also be followed.


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  1. Gco.iarc.fr. 2020. Cancer Today. [online] Available at: http://gco.iarc.fr/today/online-analysis.
  2. Raju K, Raghuveer CV, Sheela SR. Clinico pathological correlation of invasive squamous cell carcinoma of uterine cervix: a cross sectional study. Biomed Res Ther 6(11):3443–3451. DOI: 10.15419/bmrat.v6i11.573.
  3. Dikshit R, Gupta PC, Ramasundarahettige C, et al. Cancer mortality in India: a nationally representative survey. Lancet 2012;379(9828): 1807–1816. DOI: 10.1016/S0140-6736(12)60358-4.
  4. Wang T, Chen B, Yang Y, et al. Histologic and immunophenotypic classification of cervical carcinomas by expression of the p53 homologue p63: a study of 250 cases. Hum Pathol 2001;32(5): 479–486. DOI: 10.1053/hupa.2001.24324.
  5. Burd EM. Human papillomavirus and cervical cancer. Clin Microbiol Rev 2003;16(1):1–17. DOI: 10.1128/cmr.16.1.1-17.2003.
  6. Human papillomavirus (HPV) and cervical cancer [Internet]. Who.int.2020. Available from https://www.who.int/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer.
  7. Gundrajakuppam L, Vissa S, Nandam MR, et al. Clinic pathological correlation of cervical carcinoma by pap smear. J Biosci Tech 2011;2:439–445.
  8. Brisson M, Kim JJ, Canfell K, et al. Impact of HPV vaccination and cervical screening on cervical cancer elimination: a comparative modelling analysis in 78 low-income and lower-middle-income countries. The Lancet 2020;395(10224):575–590. DOI: 10.1016/S0140-6736(20)30068-4.
  9. Park KJ, Soslow RA. Current concepts in cervical pathology. Arch Pathol Lab Med 2009;133(5):729–738. DOI: 10.1043/1543-2165-133.5.729.
  10. Kumari A, Pankaj S, Choudhary V, et al. Retrospective analysis of patients of cervical cancer a tertiary center in Bihar. Indian J Cancer 2018;55(1):70–73. DOI: 10.4103/ijc.IJC_482_17.
  11. Jain DK, Shukla P, Gupta V. Clinicopathological survey of carcinoma uterine cervix in patients attending tertiary care hospital of central Uttar Pradesh. IJRPM 2019;3(2):14–17.
  12. Patil N, Deshmukh V, Rathid A, et al. Clinico Pathological correlation of cervical carcinoma: a tertiary hospital-based study int. J Sci Stud 2019;6(10):1–4.
  13. Rana MK, Singh K, Mahajan MK, et al. Clinicopathological profile of cervical carcinoma: an experience of tertiary care cancer centre. Asian Pac J Cancer Care 2019;4(3):83–86. DOI: 10.31557/apjcc.2019.4.3.83-86.
  14. Lakshmi V, Prakash HM, Jyothi BL, et al. Retrospective histopathological analysis of cervical cancer: our experience. Aerchives of Cytology and Histopathology Research 2016;1(1):28–31.
  15. Gupta M, Basavaraj PK. Histopathological spectrum of premalignant and malignant lesions of uterine cervix. national journal of laboratory medicine. 2018;7(1):PO19–PO26.
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