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VOLUME 5 , ISSUE 2 ( July-December, 2021 ) > List of Articles


To Study the Role of Urinary Uric Acid to Creatinine Ratio as a Marker of Perinatal Asphyxia and Its Severity in Newborns

Sunita Arora, Arshpuneet Kaur, Mandeep S Khurana, Jaskiran K Sandhu

Keywords : Asphyxia, HIE (Hypoxic–ischemic encephalopathy), UUA/Cr (Urinary uric acid to creatinine ratio)

Citation Information : Arora S, Kaur A, Khurana MS, Sandhu JK. To Study the Role of Urinary Uric Acid to Creatinine Ratio as a Marker of Perinatal Asphyxia and Its Severity in Newborns. Curr Trends Diagn Treat 2021; 5 (2):85-88.

DOI: 10.5005/jp-journals-10055-0133

License: CC BY-NC 4.0

Published Online: 08-12-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Objective: To compare urinary uric acid and creatinine ratio (UUA/Cr) among asphyxiated and nonasphyxiated neonates. Background: Perinatal asphyxia is the leading cause of neonatal morbidity and mortality. The last few decades have seen many improvements in modern medicine but still, there is a lack of easily available biochemical markers to diagnose perinatal asphyxia more so in institutional deliveries. Study design: Cross-sectional, comparative study. Setting: NICU and postnatal wards of tertiary care center. Participants: Forty asphyxiated and 40 healthy term newborns were enrolled in the study. Two milliliters of cord arterial blood was collected for a blood gas analysis in asphyxiated neonates only. Spot urine samples were collected within the first 24 hours of life in both asphyxiated and nonasphyxiated groups and analyzed for UUA/Cr ratio. Results: The mean UUA/Cr ratio was found to be higher in asphyxiated (2.41 ± 0.58) than in nonasphyxiated neonates (1.58 ± 0.17) (p <0.001). There was a positive correlation between the UUA/Cr ratio and the severity of hypoxic–ischemic encephalopathy among asphyxiated neonates (p <0.001). A negative correlation was found of UUA/Cr ratio with Apgar score and umbilical cord blood pH. The cutoff value of the UUA/Cr ratio of 1.36 has 97.5% sensitivity, 100% specificity, 100% positive predictive value, 97.5% negative predictive value, and 98.7% accuracy. Conclusion: This ratio can be used as a reliable diagnostic marker to detect perinatal asphyxia in neonates where adequate birth history is not available.

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