AMEI's Current Trends in Diagnosis & Treatment

Register      Login

VOLUME 5 , ISSUE 2 ( July-December, 2021 ) > List of Articles


A Rare Case of Left Atrial Mass with Nonhemorrhagic Infarct in a Patient of Inherited Thrombophilia

Hargurdas Singh, Gurinder Mohan, Jivtesh Preet Singh, Akansha, Kapeesh Khanna

Keywords : Cardioembolic stroke, Intracardiac mass, Nonhemorrhagic infarct, Protein S

Citation Information : Singh H, Mohan G, Singh JP, A, Khanna K. A Rare Case of Left Atrial Mass with Nonhemorrhagic Infarct in a Patient of Inherited Thrombophilia. Curr Trends Diagn Treat 2021; 5 (2):107-109.

DOI: 10.5005/jp-journals-10055-0134

License: CC BY-NC 4.0

Published Online: 08-12-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Inherited thrombophilias are a group of inheritable conditions that predispose individuals to venous or arterial thrombosis like deficiencies of the endogenous anticoagulants protein S, protein C, antithrombin, etc. Protein S deficiency is associated with a well-documented risk of venous thromboembolism but arterial thrombotic and thromboembolic events are very rare. Intracardiac masses are mass lesions present in either ventricles or atrium and include benign or malignant cardiac tumors, thrombus, or vegetation as well as infectious and nonbacterial thrombotic or marantic endocarditis. Cardioembolic stroke has been reported previously in patients with intracardiac masses like atrial myxoma, cardiac sarcoma, mitral stenosis with atrial fibrillation but very rare in Protein S deficiency. We report a case of embolic ischemic stroke due to intracardiac mass in a known case of protein S deficiency.

  1. Fearon A, Pearcy P, Venkataraman S, et al. Protein S deficiency and arterial thromboembolism: a case report and review of the literature. J Hematol 2019;8(1):37–39. DOI: 10.14740/jh478.
  2. Ormesher L, Simcox L, Tower C, et al. Management of inherited thrombophilia in pregnancy. Womens Health(Lond) 2016;12(4): 433–441. DOI: 10.1177/1745505716653702.
  3. Patel ML, Sachan R, Seth G. Combined deficiency of proteins C and S: ischaemic stroke in young individuals. BMJ Case Rep 2013;2013:bcr2012008016. DOI: 10.1136/bcr-2012-008016.
  4. Pantam N, Pulloori M, Alugubelly K. Stroke in young with primary protein–S deficiency. J Assoc Physicians India 2014;62(10):74–75. PMID: 25906532.
  5. Rawat RS, Mehta Y, Arora D, et al. Asymptomatic type B right atrial thrombus in a case with protein S deficiency. Ann Card Anaesth 2014;17(3):237–239. DOI: 10.4103/0971-9784.135877.
  6. Ok EJ, Kim HW, Kim SD, et al. Multivessel thromboembolism associated with dysfunction of protein s. Ann Rehabil Med 2012;36(3):414–417. DOI: 10.5535/arm.2012.36.3.414.
  7. Pahuja M, Ainapurapu B, Abidov A. Large left ventricular thrombus in a patient with systemic and venous thromboembolism secondary to protein C and S deficiency. Case Rep Cardiol 2017;2017:7576801. DOI: 10.1155/2017/7576801.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.